Mark,
A reply email has no relation to ClickDimensions. The replies are just like any email sent directly to you or to whichever email address you had set as the "from" address when you sent the original email via ClickDimensions. Replies do not go through our system and do not report anything back to our system. And just as with any other email you receive in your Outlook, you can track any reply you receive using CRM's Outlook add-in.