Hi Jenn,
Sorry for the trouble! Are you using IE? If so, I've often seen a pop-up appear as soon as the iframe is embedded in an HTML block in the Landing Page. If you click on it to "display all content", it refreshes the page without saving your changes. Could this be happening? If you need further help with this, I would recommend opening a support ticket at http://support.clickdimensions.com so that we can de-bug your specific page.
Thank you!